Correlation Between Nasal and Laryngeal Lesions of Rhinoscleroma in Patients of Upper Egypt

J Voice. 2022 Jul;36(4):587.e13-587.e20. doi: 10.1016/j.jvoice.2020.07.017. Epub 2020 Aug 19.


Introduction: Rhinoscleroma (RS) is a chronic granulomatous disease of URT caused by Klebsiella Rinoescleromatis. RS is considered endemic in Egypt. The nasal mucosa represents the primary region of occurrence. The disease can potentially spread to involve the larynx and trachea causing dysphonia, stridor, and airway obstruction.

Objectives: To describe various nasal and laryngeal presentations of RS in our endemic area, to correlate between these findings and to alert physicians to suspect RS in any case of unexplained nasal or laryngeal lesion.

Methods: The study included 100 patients admitted in our otorhinolaryngolgy department (Minia University, Minia, Egypt). Patients presented with various manifestations of Rhino-pharyngo-laryngo scleroma. Diagnosis based on clinical, bacteriological, and pathological examination.

Results: Patients had typical nasal stages of RS, however; only 12 % of patients had the typical described laryngeal presentations (ie, subglottic narrowing and subglottic membrane). Other patients presented with atypical laryngeal presentations (eg, unhealthy vocal folds, ventricular fold hypertrophy, and suproglottic sticky greenish discharge). There was significant correlation between nasal stages and laryngeal lesions.

Conclusion: RS can present with atypical laryngeal presentations in endemic areas which should be kept in mind to avoid misdiagnosis. Possible laryngeal lesions of RS can be predicted from observing associated nasal lesions.

Keywords: Histopathology; Hoarseness; Larynx; Rhinoscleroma.

MeSH terms

  • Egypt / epidemiology
  • Humans
  • Larynx* / pathology
  • Nose
  • Rhinoscleroma* / diagnosis
  • Rhinoscleroma* / epidemiology
  • Rhinoscleroma* / pathology
  • Trachea / pathology