Stimulation of glucagon release by addition of anti-stomatostatin serum to islets of Langerhans in vitro

Endocrinology. 1977 Aug;101(2):635-8. doi: 10.1210/endo-101-2-635.


Addition of anti-somatostatin serum to rat islets of Langerhans which had been previously maintained in organ culture for 48h, resulted in a marked stimulation of glucagon release with no change in the rate of insulin secretion during the entire 90 min period during which the secretion of both hormones was followed. Prior saturation of the anti-somatostatin serum with somatostatin prevented the stimulatory acting on glucagon release. These data strongly suggest a physiological role for endogenous somatostatin in the control of glucagon secretion.

MeSH terms

  • Animals
  • Cells, Cultured
  • Glucagon / metabolism*
  • Immune Sera / pharmacology
  • Insulin / metabolism
  • Insulin Secretion
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism
  • Rats
  • Somatostatin / immunology
  • Somatostatin / pharmacology*


  • Immune Sera
  • Insulin
  • Somatostatin
  • Glucagon