Biological roles of piRNAs in colorectal cancer

Zhuang Jing; Yang Xi; Jin Yin; Han Shuwen

doi:10.1016/j.gene.2020.145063

Biological roles of piRNAs in colorectal cancer

Gene. 2021 Feb 15:769:145063. doi: 10.1016/j.gene.2020.145063. Epub 2020 Aug 19.

Authors

Zhuang Jing¹, Yang Xi², Jin Yin³, Han Shuwen⁴

Affiliations

¹ Graduate School of Nursing, Huzhou University, Zhejiang, No. 1 Bachelor Road, Huzhou, Zhejiang Province 313000, PR China.
² Department of Oncology, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, 198 Hongqi Rd, Huzhou, Zhejiang 313000, PR China.
³ Department of Laboratory Medicine, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, 198 Hongqi Rd, Huzhou, Zhejiang 313000, PR China.
⁴ Department of Oncology, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, 198 Hongqi Rd, Huzhou, Zhejiang 313000, PR China. Electronic address: shuwenhan985@163.com.

PMID: 32827685
DOI: 10.1016/j.gene.2020.145063

Abstract

Colorectal cancer (CRC) is one of the most common malignancies worldwide and a major cause of cancer-related deaths. Numerous studies have suggested that piwi-interacting RNAs (piRNAs), a new type of non-coding RNA (ncRNA), are closely related to the occurrence and development of cancer. piRNAs have been shown to regulate the occurrence of CRC by modulating multiple molecular signaling pathways. Here, the roles of piRNAs in CRC were reviewed to provide evidence for their potential as molecular targets for CRC.

Keywords: Colorectal cancer; piRNA; piwi-interacting RNA; piwiRNA.

Publication types

Review

MeSH terms

Animals
Colorectal Neoplasms / genetics*
Humans
RNA, Small Interfering / physiology*

Substances

RNA, Small Interfering