Clinicopathological and radiological characterization of myofibroblastoma of breast: A single institutional case review

Ann Diagn Pathol. 2020 Oct:48:151591. doi: 10.1016/j.anndiagpath.2020.151591. Epub 2020 Aug 15.


Myofibroblastoma is a rare type of benign myofibroblastic neoplasm in the breast. It is clinically presented as a well-circumscribed mass, usually small in size (usually less than 4.0 cm), and can mostly be cured by local excision. Rare cases of giant myofibroblastoma greater than 10 cm have been reported, but also follow a benign clinical course. Histologically, breast myofibroblastoma is featured by bland fascicles of spindle cells intermixed with thick hyalinized collagen bundles. Mast cells are frequently found within the stroma. However, a wide spectrum of morphological variants can occur in myofibroblatoma, making its diagnosis challenging sometimes. Differential diagnosis of myofibroblastoma with other spindle cell lesions in the breast, either benign or malignant, is also important in practice. In this study, we collected 15 cases of breast myofibroblastoma diagnosed in our institution during a 20 year period. The sizes of these cases range from 0.4 cm to 35.2 cm (mean is 3.7 cm). To our knowledge, the case of giant breast myofibroblastoma we presented here is the largest one reported to date. The histological examination of the cases show great morphological variations. Besides the classical type, features of cellular, collagenized, palisading, epithelioid, myxoid, myoid, solitary fibrous tumor-like are also identified in the case series. Immunohistochemical staining patterns as well as clinical features of the cases are also summarized and compared. All cases in this study show no recurrence on follow-up. In addition, cases that are important differential diagnosis for breast myofibroblastoma are also studied. Their key histological characteristics are compared with myofibroblastoma, and their immunohistochemical and molecular features are discussed.

Keywords: Breast; Clinicopathology; Differential; Myofibroblastoma; Radiology.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Angiomatosis / diagnosis
  • Antigens, CD34 / metabolism
  • Biomarkers, Tumor / metabolism*
  • Biopsy
  • Breast Diseases / diagnosis
  • Breast Neoplasms / pathology*
  • Collagen / metabolism
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyperplasia / diagnosis
  • Immunohistochemistry / methods
  • Mammography / methods
  • Middle Aged
  • Neoplasms, Muscle Tissue / diagnosis*
  • Neoplasms, Muscle Tissue / metabolism*
  • Neoplasms, Muscle Tissue / surgery
  • Solitary Fibrous Tumors / diagnosis
  • Ultrasonography / methods
  • Vimentin / metabolism


  • Antigens, CD34
  • Biomarkers, Tumor
  • Vimentin
  • Collagen

Supplementary concepts

  • Pseudoangiomatous stromal hyperplasia