Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin

FEBS Lett. 1988 Apr 25;231(2):440-4. doi: 10.1016/0014-5793(88)80867-6.


A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA / genetics
  • Endothelin-1
  • Endothelins
  • Humans
  • Molecular Sequence Data
  • Peptides / genetics*
  • Placenta / analysis
  • Protein Precursors / genetics*
  • Sequence Homology, Nucleic Acid
  • Swine / genetics


  • Endothelin-1
  • Endothelins
  • Peptides
  • Protein Precursors
  • DNA

Associated data

  • GENBANK/Y00749