Abstract
Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / metabolism
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Animals
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Brain / enzymology
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Cathepsin D / metabolism*
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Diabetes Mellitus, Experimental / drug therapy
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Diabetes Mellitus, Experimental / enzymology*
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Insulin / pharmacology*
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Insulin / therapeutic use
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Kidney / enzymology
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Liver / enzymology
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Lysosomes / enzymology*
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Male
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Myocardium / enzymology
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Rats
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Rats, Inbred Strains
Substances
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Amino Acids
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Insulin
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Cathepsin D