Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart

Diabetologia. 1988 Feb;31(2):119-22. doi: 10.1007/BF00395559.

Abstract

Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / metabolism
  • Animals
  • Brain / enzymology
  • Cathepsin D / metabolism*
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Experimental / enzymology*
  • Insulin / pharmacology*
  • Insulin / therapeutic use
  • Kidney / enzymology
  • Liver / enzymology
  • Lysosomes / enzymology*
  • Male
  • Myocardium / enzymology
  • Rats
  • Rats, Inbred Strains

Substances

  • Amino Acids
  • Insulin
  • Cathepsin D