NAFLD fibrosis score (NFS) can be used in outpatient services to identify chronic vascular complications besides advanced liver fibrosis in type 2 diabetes

Rosa Lombardi; Lorena Airaghi; Giovanni Targher; Gaetano Serviddio; Gabriele Maffi; Alessandro Mantovani; Claudio Maffeis; Antonio Colecchia; Rosanna Villani; Luca Rinaldi; Emanuela Orsi; Giuseppina Pisano; Luigi Elio Adinolfi; Silvia Fargion; Anna Ludovica Fracanzani

doi:10.1016/j.jdiacomp.2020.107684

NAFLD fibrosis score (NFS) can be used in outpatient services to identify chronic vascular complications besides advanced liver fibrosis in type 2 diabetes

J Diabetes Complications. 2020 Nov;34(11):107684. doi: 10.1016/j.jdiacomp.2020.107684. Epub 2020 Jul 17.

Authors

Affiliations

¹ Department of Pathophysiology and Transplantation Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Italy. Electronic address: rosa.lombardi@unimi.it.
² Department of Pathophysiology and Transplantation Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Italy.
³ Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy.
⁴ Centro C.U.R.E, Dept. of Medical and Surgical Sciences, University of Foggia, Italy.
⁵ Pediatric Diabetes and Metabolic Disorders Unit, Department of Surgical Sciences, Dentistry, and Pediatrics, and Gynaecology, University Hospital of Verona, Verona, Italy.
⁶ Gastroenterology Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
⁷ Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli" Naples, Italy.
⁸ Department of Medical Science, Endocrinology and Diabetes Unit, Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Italy.

PMID: 32829997
DOI: 10.1016/j.jdiacomp.2020.107684

Abstract

We demonstrate in 351 diabetic patients with steatosis that NAFLD fibrosis score (NFS), a rapid and affordable score to diagnose hepatic fibrosis, identifies patients at higher risk of advanced fibrosis and vascular diabetic complications (especially peripheral neuropathy), pointing NFS as a first-line vascular and hepatic screening in diabetic patients.

Keywords: Diabetic neuropathy; Microvascular complications; NAFLD; Non-invasive diagnosis; Stroke; Type 2 diabetes screening.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ambulatory Care
Cardiovascular Diseases* / complications
Cardiovascular Diseases* / diagnosis
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / diagnosis
Humans
Liver Cirrhosis* / complications
Liver Cirrhosis* / diagnosis
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / diagnosis