A simple artificial diet available for research of silkworm disease models

Drug Discov Ther. 2020 Sep 8;14(4):177-180. doi: 10.5582/ddt.2020.03061. Epub 2020 Aug 24.


This study was performed with the aim of making a very simple recipe of silkworm diet for research purposes, especially screening of drug candidates. We prepared a diet containing mulberry leaves powder and soybean flour at different ratios, fed them to fifth instar silkworm larvae, and observed their growth. We selected the diet with 1:1 ratio of mulberry powder and soybean flour, named MS-11, and used for further experiments. MS-11 diet was available for oral administration of drugs in silkworm hyperglycemic model and infection model. The availability of a simple artificial diet for experiments that require feeding silkworms will enhance the use of silkworms for biological, biotechnological, and pharmacological researches.

Keywords: Silkworm; artificial diet; mulberry; research.

MeSH terms

  • Animal Feed
  • Animals
  • Bombyx / growth & development*
  • Drug Evaluation, Preclinical
  • Larva / growth & development
  • Models, Animal
  • Morus / chemistry*
  • Plant Extracts / administration & dosage*
  • Soybeans / chemistry*


  • Plant Extracts