Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance

Xiaoxu Kang; Yushu Wang; Zhigang Chen; Yixin Wu; Hao Chen; Xi Yang; Changyuan Yu

doi:10.1039/d0cc01846e

Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance

Chem Commun (Camb). 2020 Sep 28;56(76):11271-11274. doi: 10.1039/d0cc01846e. Epub 2020 Aug 24.

Authors

Xiaoxu Kang¹, Yushu Wang, Zhigang Chen, Yixin Wu, Hao Chen, Xi Yang, Changyuan Yu

Affiliation

¹ College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, P. R. China. yucy@mail.buct.edu.cn.

PMID: 32830841
DOI: 10.1039/d0cc01846e

Abstract

An imidazole modified Pt(iv) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Survival / drug effects
Cisplatin / chemistry
Cisplatin / pharmacology*
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm / drug effects*
Drug Screening Assays, Antitumor
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Imidazoles / chemistry
Imidazoles / pharmacology*
Lipids / chemistry
Lipids / pharmacology
Molecular Structure
Nanoparticles / chemistry*
Particle Size
Platinum / chemistry
Platinum / pharmacology*
Prodrugs / chemical synthesis
Prodrugs / chemistry
Prodrugs / pharmacology*
Static Electricity
Surface Properties

Substances

Antineoplastic Agents
Imidazoles
Lipids
Prodrugs
Platinum
imidazole
Cisplatin