Regulation of peanut-specific CD8 + T cells from nonallergic individuals

J Allergy Clin Immunol. 2021 Jan;147(1):385-387.e1. doi: 10.1016/j.jaci.2020.07.032. Epub 2020 Aug 21.

Abstract

Peanut-specific CD8+ T cells in nonallergic individuals are not deleted, but have an expansion block that can be released by impairing regulatory T cell associated signaling pathways.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Plant
  • Arachis / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Female
  • Follow-Up Studies
  • HLA-A2 Antigen / immunology*
  • Humans
  • Male
  • Membrane Proteins
  • Plant Proteins

Substances

  • Antigens, Plant
  • Ara h 1 protein, Arachis hypogaea
  • HLA-A*02:01 antigen
  • HLA-A2 Antigen
  • Membrane Proteins
  • Plant Proteins