The novel coronavirus 2019-nCoV: Its evolution and transmission into humans causing global COVID-19 pandemic

Y R Rastogi; A Sharma; R Nagraik; A Aygün; F Şen

doi:10.1007/s13762-020-02781-2

The novel coronavirus 2019-nCoV: Its evolution and transmission into humans causing global COVID-19 pandemic

Int J Environ Sci Technol (Tehran). 2020;17(10):4381-4388. doi: 10.1007/s13762-020-02781-2. Epub 2020 May 26.

Authors

Y R Rastogi¹, A Sharma¹, R Nagraik¹, A Aygün², F Şen²

Affiliations

¹ Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh 173229 India.
² Sen Research Group, Biochemistry Department, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey.

Abstract

A novel coronavirus strain 2019-nCoV has caused a rapid global pandemic-COVID-19. Scientists have taken onto the task of characterizing this new virus and understanding how this virus has transmitted to humans. All preliminary studies have found some striking similarities between this new virus and the SARS-CoV that caused a similar kind of epidemic in 2002-2003. Through bioinformatics tools, a great deal of information has been gathered about the origin, evolution and zoonosis of this virus. We, in this review, report the symptoms, mode of transmission and available and putative treatments to tackle 2019-nCoV infections. We also comprehensively summarize all the information so far made available regarding the genome, evolution and zoonosis of this virus.

Keywords: 2019-nCoV; COVID-19; Homologous recombination; Phylogenetic analysis; RdRp enzyme; Receptor binding domain (RBD); Spike glycoprotein; orf1a/b.

Publication types

Review