Remdesivir and its antiviral activity against COVID-19: A systematic review

Clin Epidemiol Glob Health. 2020 Aug 7. doi: 10.1016/j.cegh.2020.07.011. Online ahead of print.

Abstract

Background: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.

Methods: Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.

Results: Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Remdesivir has been used as a compassionate drug for treating COVID-19 patients.

Conclusion: Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.

Keywords: COVID-19; Clinical trial; Remdesivir; SARS-CoV-2; Treatment.

Publication types

  • Review