Randomized controlled trial of oral bicarbonate treatment for labor stagnation

J Obstet Gynaecol Res. 2021 Jan;47(1):114-118. doi: 10.1111/jog.14438. Epub 2020 Aug 24.

Abstract

Aim: The aim of this study was to determine the effect of oral sodium bicarbonate solution on delivery outcome of primiparous women with labor stagnation.

Methods: This randomized controlled trial study was performed on 142 primiparous pregnant women referred to Jiroft University hospitals who had stagnation during labor. In the intervention group, in addition to oxytocin, 4.26 g of sodium bicarbonate dissolved in 200 mL of water were given orally. The control group received only oxytocin. Data were analyzed by t-test and chi-square test.

Results: The mean interval of dilatation stopping to delivery in the intervention group was significantly lower than the control group (202.34 vs 304.08 min, P = 0.001). The mean duration of the first and second stages of labor in the intervention group was lower than the control group (280.44 vs 397.16 and 35.00 vs 51.72 min respectively, P = 0.001). There was no statistically significant difference between the intervention and control groups in the rate of cesarean section and Apgar score. In the intervention group, the rate of spontaneous delivery was significantly higher (65 vs 56 cases, P = 0.03) than the control group.

Conclusion: The results of the present study could suggest the use of oral bicarbonate in stagnation as a cheap and no-cost method to facilitate normal vaginal delivery.

Keywords: oral sodium bicarbonate; primiparous; stagnation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Bicarbonates
  • Cesarean Section*
  • Delivery, Obstetric
  • Female
  • Humans
  • Labor, Induced
  • Labor, Obstetric*
  • Oxytocin
  • Pregnancy
  • Trial of Labor

Substances

  • Bicarbonates
  • Oxytocin