Objective:To investigate the clinical characteristics, diagnosis and treatment of female laryngeal contact granuloma. Method:The clinical data of 46 female patients with laryngeal contact granuloma diagnosed and treated by our clinical team from March 2011 to October 2018 were retrospectively analyzed. Result:The age of the 46 patients ranged from 5 to 58 years old, with an average age of 36.76 years old. The causes of the contact granulomas historically may be the result of intubation in 33 cases, laryngopharyngeal reflux in 8 cases, chronic cough in 2 cases, laryngopharyngeal reflux combined with chronic cough in 2 cases, and voice abuse and excessive clearing of the throat in one case. All patients were followed up for at least half a year, and all of them were cured. Among the 6 patients with large lesions who underwent surgical treatment, 3 relapsed within 3 months, PPI treatment was performed for 2 to 6 months after recurrence, and no recurrence was observed during follow-up, with an average course of treatment of （1.67±2.34） months. All the 11 patients who received corticosteroid injections recovered after 1 to 7 injections, with a median of 3 injections, and an average course of treatment of （2.64±1.69） months. All the 13 patients with oral PPI were cured, with an average course of treatment of （4.15±2.76 ）months; No recurrence was found in the follow-up of 16 patients with conservative treatment under regular observation, with an average course of treatment of （5.88±3.76） months. The difference in cure time between the intervention group （30 cases） and the observation group （16 cases） was statistically significant, and the cure time of the intervention group was shorter than that of the observation group （H=11.902, P=0.008）. Conclusion:Female patients with laryngeal contact granuloma are common after intubation, and various treatments or conservative observation can achieve good results, and treatment intervention may shorten the cure time.
目的：探讨女性喉接触性肉芽肿的临床特点、诊断及治疗方法。 方法：对2011-03-2018-10期间诊治的46例女性喉接触性肉芽肿患者的临床资料进行回顾分析。 结果：46例患者，插管后33例，咽喉反流8例，慢性咳嗽2例，咽喉反流合并慢性咳嗽2例，用声过度及过分清理喉咙1例。所有患者至少随访半年以上，全部治愈，6例病变较大行手术治疗的患者3个月内复发3例，复发后质子泵抑制剂治疗2~6个月，随访至今未见再次复发，疗程（1.67±2.34）个月；11例糖皮质激素注射患者全部痊愈，注射1~7次，疗程（2.64±1.69）个月；13例口服抑酸药物患者全部治愈，疗程（4.15±2.76）个月；16例定期观察下保守治疗患者随访至今未见复发，疗程（5.88±3.76）个月。干预组（30例）与观察组（16例）的治愈时间差异有统计学意义，干预组治愈时间短于观察组（H=11.902，P=0.008）。 结论：女性喉接触肉芽肿病患者常见于插管后，各种治疗或保守观察均能取得较好效果，治疗干预可能缩短治愈时间。.
Keywords: diagnosis; granuloma, laryngeal; treatment; woman.
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