[Study on the correlation between dietary N-glycolylneuraminic acid intake and chronic inflammation state of body]

Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Jun 6;54(6):668-672. doi: 10.3760/cma.j.cn112150-20191021-00802.
[Article in Chinese]


Objective: To explore the correlation between dietary N-glycolylneuraminic acid (Neu5Gc) intake and chronic inflammation state of body. Methods: A total of 306 samples of 102 types of food were purchased from a supermarket in Xiamen in September 2019, including grains, meat, poultry, seafood, eggs, beans, dairy products, vegetables and fruits. The content of Neu5Gc in food was determined by liquid chromatography-mass spectrometry. A total of 500 healthy freshmen from Xiamen University were selected by using a simple random sampling method. The food frequency questionnaire was used to investigate the food intake in the past year. The food intake was corrected by 3 consecutive 24-hour recalls, and the amount of Neu5Gc intake was calculated. The concentration of anti-Neu5Gc antibody, C-reactive protein (CRP) and interleukin-6 (IL-6) in serum was detected. Spearman correlation analysis was used to explore the correlation between Neu5Gc intake and anti-Neu5Gc antibody, CRP and IL-6 levels. Results: Neu5Gc was mainly found in red meat and liquid dairy products. The contents of Neu5Gc in beef, lamb and pork were (30.32±2.84), (20.39±4.73) and (5.58±1.04) mg/kg, respectively, and in liquid milk and yogurt were (10.87±1.54) and (6.91±0.24) mg/L, respectively. The M (P25, P75) intake of Neu5Gc for all participants was 4.62 (2.20, 8.60) mg/d. The M(P25, P75) intake of Neu5Gc for males about 6.60(2.83, 10.20) was higher than that for females about [3.84 (1.84, 6.35) mg/d] (P<0.001). The M (P25, P75) of serum anti-Neu5Gc, CRP and IL-6 levels were 3.07 (2.17, 4.14) μg/ml, 0.37 (0.22, 0.87) mg/ml and 61.82 (12.23, 315.30) pg/ml, respectively. Spearman correlation analysis showed that the intake level of Neu5Gc was positively correlated with serum anti-Neu5Gc antibody, CRP and IL-6 levels, with rs values about 0.222, 0.102 and 0.126, respectively (all P values <0.05). Conclusion: Dietary Neu5Gc intake is mainly from red meat and liquid dairy products, and its intake level is positively correlated with chronic inflammatory state of body.

目的: 探讨膳食N-羟乙酰神经氨酸(Neu5Gc)摄入水平与机体慢性炎症状态的关系。 方法: 所有食物样品均于2019年9月购自厦门某超市,包括谷物、肉类、家禽、海鲜、鸡蛋、豆类、乳制品、蔬菜和水果等,共计102种306份,采用液相色谱-质谱联用法测定食物Neu5Gc含量。采用简单随机抽样抽取厦门大学健康入学新生500名,采用食物频率调查表调查研究对象过去1年内食物摄入情况,采用连续3 d 24 h回顾法校正食用量,计算对象的Neu5Gc摄入量。检测血清抗-Neu5Gc抗体、C反应蛋白(CRP)和白细胞介素-6(IL-6)水平。采用Spearman相关分析探索Neu5Gc摄入量与抗-Neu5Gc抗体以及CRP和IL-6等指标的相关性。 结果: Neu5Gc主要存在于红肉和液态乳制品,在牛、羊和猪肉中的含量分别为(30.32±2.84)、(20.39±4.73)和(5.58±1.04)mg/kg,在液态牛奶和酸奶中的含量分别为(10.87±1.54)和(6.91±0.24)mg/L。Neu5Gc摄入量的MP25P75)为4.62(2.20,8.60)mg/d,其中男生为6.60(2.83,10.20)mg/d,高于女生[3.84(1.84,6.35) mg/d](P<0.001)。血清抗-Neu5Gc、CRP和IL-6水平的MP25P75)分别为3.07(2.17,4.14)μg/ml,0.37(0.22,0.87)mg/ml和61.82(12.23,315.30)pg/ml。Neu5Gc摄入水平与血清抗-Neu5Gc抗体、CRP和IL-6水平均呈正相关,rs值分别为0.222、0.102和0.126,P值均<0.05。 结论: 膳食Neu5Gc摄入主要来自红肉和液态乳制品,其摄入水平与机体慢性炎症状态呈正相关。.

Keywords: Cross-sectional studies; Diet; Inflammation; Sialic acids.

MeSH terms

  • Animals
  • Cattle
  • Diet
  • Female
  • Inflammation*
  • Male
  • Meat / analysis
  • Neuraminic Acids*
  • Sheep


  • Neuraminic Acids
  • N-glycolylneuraminic acid