TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway

Signal Transduct Target Ther. 2020 Aug 25;5(1):163. doi: 10.1038/s41392-020-00276-7.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Proliferation / genetics
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • HCT116 Cells
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • MAP Kinase Kinase 3 / genetics*
  • Matrix Metalloproteinase 1 / genetics
  • Matrix Metalloproteinase 9 / genetics*
  • NF-kappa B / genetics
  • Neoplasm Invasiveness / genetics
  • Neoplasm Invasiveness / pathology
  • Neoplasm Metastasis
  • Signal Transduction / genetics
  • p38 Mitogen-Activated Protein Kinases / genetics

Substances

  • Intracellular Signaling Peptides and Proteins
  • NF-kappa B
  • TNFAIP8L1 protein, human
  • p38 Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 3
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 1