ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity

Biochem Biophys Rep. 2020 Dec:24:100798. doi: 10.1016/j.bbrep.2020.100798. Epub 2020 Aug 20.

Abstract

The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants' analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.

Keywords: ACE2 variants; Populations; SARS-CoV-2 binding; Single nucleotide variants.