Expression of class II MHC gene products by macrophages in human uteroplacental tissue

Immunology. 1988 Apr;63(4):707-14.

Abstract

The expression of class II MHC determinants by fetal and maternal macrophages in human uteroplacental tissues was examined with monoclonal antibodies directed against HLA-DR, DP and DQ antigens. Maternal macrophages in early and full-term pregnancy decidua were HLA-DR positive, and a substantial proportion also expressed DP and DQ antigens. Fetal macrophages in chorionic villous stroma in first-trimester pregnancy were rarely HLA-DR positive, and DQ and DP antigens were never expressed. In term placental tissues, groups of villous stromal macrophages were HLA-DR positive, as were fetal macrophages within amniotic mesenchyme. In contrast, DP and DQ antigens were detected on a small minority of fetal macrophages in term placental tissues. DP and DQ antigens were not detected in the absence of DR antigens.

MeSH terms

  • Chorionic Villi / immunology
  • Decidua / immunology
  • Extraembryonic Membranes / immunology
  • Female
  • Fetus / immunology*
  • HLA-D Antigens / analysis*
  • Humans
  • Immunoenzyme Techniques
  • Macrophages / immunology*
  • Placenta / immunology*
  • Pregnancy / immunology*
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Third

Substances

  • HLA-D Antigens