The Effect of 0.01% Atropine Eye Drops on the Ocular Surface in Children for the Control of Myopia-The Primary Results from a Six-Month Prospective Study

Ther Clin Risk Manag. 2020 Aug 10;16:735-740. doi: 10.2147/TCRM.S265945. eCollection 2020.

Abstract

Purpose: To evaluate the effect of 0.01% atropine eye drops on the ocular surface in children for the control of myopia.

Methods: A total of 72 participants were recruited for this prospective study. Prior to and after 1, 3, and 6 months of 0.01% atropine administration, an ocular surface disease index (OSDI) questionnaire was obtained, Keratograph 5M was used for the measurement of the tear meniscus height (TMH), noninvasive keratographic tear film break-up time (NK-BUT, the first keratographic break-up time, [NK-BUTfirst] and the average keratographic break-up time, [NK-BUTave]), bulbar redness (BR), meiboscore (MS), and anterior segment optical coherence tomography (AS-OCT) was used to calculate the inferior tear meniscus area (TMA).

Results: After using the 0.01% atropine eye drops for 1 month, 9 subjects complained of discomfort immediately after administration, but this quickly subsided, and 1 subject was temporarily dazzled. All the ocular surface symptoms were mild and occurred rarely. After 3 months, these complaints no longer occurred. Compared with the baseline values, the OSDI scores (0.08 ± 0.28), values of TMH (0.23 ± 0.04 mm), TMA (0.0420 ± 0.0444 mm2), NK-BUTfirst (9.39 ± 5.25 s), NK-BUTave (10.49 ± 4.94 s), BR (0.63 ± 0.37), and MS (0.89 ± 0.70) did not change significantly after 6 months of 0.01% atropine eye drop administration (P > 0.05).

Conclusion: In this 6-month prospective study, no side effects were observed on the ocular surface after using 0.01% atropine in children.

Keywords: 0.01% atropine eye drops; children; myopia control; ocular surface.

Grant support

This research was supported by Shanghai Committee of Science and Technology Foundation (Grant No.19441901000). The sponsor and funding organization had no role in the design or conduct of this research.