Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers

Onco Targets Ther. 2020 Aug 5;13:7699-7717. doi: 10.2147/OTT.S267140. eCollection 2020.

Abstract

Long non-coding RNAs (lncRNAs) are emerging regulators of a diverse range of biological processes through various mechanisms. Genome-wide association studies of tumor samples have identified several lncRNAs, which act as either oncogenes or tumor suppressors in various types of cancers. Small nucleolar RNAs (snoRNAs) are predominantly found in the nucleolus and function as guide RNAs for the processing of transcription. As the host genes of snoRNAs, lncRNA small nucleolar RNA host genes (SNHGs) have been shown to be abnormally expressed in multiple cancers and can participate in cell proliferation, tumor progression, metastasis, and chemoresistance. Here, we review the biological functions and emerging mechanisms of SNHGs involved in the development and progression of endocrine-related cancers including thyroid cancer, breast cancer, pancreatic cancer, ovarian cancer and prostate cancer.

Keywords: SNHG; cancers; endocrine; lncRNA.

Publication types

  • Review

Grant support

This project was funded by the National Natural Science Foundation of China (grant number 81902726), the China Postdoctoral Science Foundation (grant number 2018M641739), and the Natural Science Foundation of Liaoning Province (grant number 20180530090).