The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology

Yajin Liao; Yuan Dong; Jinbo Cheng

doi:10.3389/fncel.2020.00194

The Molecular Determinants of Mitochondrial Membrane Contact With ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology

Front Cell Neurosci. 2020 Aug 7:14:194. doi: 10.3389/fncel.2020.00194. eCollection 2020.

Authors

Yajin Liao¹, Yuan Dong², Jinbo Cheng¹

Affiliations

¹ Center on Translational Neuroscience, College of Life & Environmental Science, Minzu University of China, Beijing, China.
² Department of Biochemistry, Medical College, Qingdao University, Qingdao, China.

Abstract

Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediate the membrane contact between mitochondria and other organelles, and their functions, have been revealed in recent years. In this review article, we aim to summarize the findings on the tethering between mitochondria and other organelles in physiological or pathological conditions, and discuss their roles in cellular homeostasis, neural activity, and neurodegenerative diseases.

Keywords: determinant; membrane contact; mitochondria; neurological diseases; pathological condition; physiological condition.