Hypoxia-Inducible Factor Is Critical for Pathogenesis and Regulation of Immune Cell Functions in Rheumatoid Arthritis

Front Immunol. 2020 Jul 28:11:1668. doi: 10.3389/fimmu.2020.01668. eCollection 2020.

Abstract

Rheumatoid arthritis (RA) is a common autoimmune disease with characteristics of synovial inflammation, pannus formation, cartilage destruction, and bone erosion. Further, the inflammation is linked to increased oxygen consumption, resulting in hypoxia within the inflammatory area. Hypoxia-inducible factor (HIF) was reported to be associated with adaptation to the hypoxic microenvironment in the RA synovium. Here, we have briefly summarized the structure and expression of HIF. Moreover, the function of HIF in inflammation, angiogenesis, cartilage damage, and immune cells of RA has been discussed.

Keywords: bone erosion; cartilage destruction; hypoxia; hypoxia-inducible factor; inflammation; pannus formation; rheumatoid arthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / metabolism*
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / metabolism*
  • Arthritis, Rheumatoid / pathology
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Cell Hypoxia
  • Cellular Microenvironment
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Inflammation Mediators / metabolism
  • Joints / immunology
  • Joints / metabolism*
  • Joints / pathology
  • Myeloid Cells / immunology
  • Myeloid Cells / metabolism*
  • Neovascularization, Pathologic
  • Repressor Proteins / metabolism*
  • Signal Transduction
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism*

Substances

  • Apoptosis Regulatory Proteins
  • Basic Helix-Loop-Helix Transcription Factors
  • HIF1A protein, human
  • HIF3A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Inflammation Mediators
  • Repressor Proteins
  • endothelial PAS domain-containing protein 1