Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

Xianfa Xuan; Jincheng Lin; Yiqin Zhang; Lina Zhou; Liping Xu; Junlu Jia; Benhua Zhao; Zhiyang Lin; Qiong Zhu; Lianmeng Li; Ting Wu; Siyu Zhang; Hanxiang Jiang; Yuxin Wang

doi:10.14740/jocmr4261

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

J Clin Med Res. 2020 Sep;12(9):612-617. doi: 10.14740/jocmr4261. Epub 2020 Aug 15.

Authors

Xianfa Xuan^{1

2}, Jincheng Lin^{3

2}, Yiqin Zhang¹, Lina Zhou¹, Liping Xu¹, Junlu Jia⁴, Benhua Zhao⁴, Zhiyang Lin⁵, Qiong Zhu⁵, Lianmeng Li³, Ting Wu¹, Siyu Zhang¹, Hanxiang Jiang^{3

2}, Yuxin Wang^{1

2}

Affiliations

¹ Department of Nephrology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China.
² They contributed equally to this work.
³ Department of General Practice, Guankou Hospital, Jimei District, Xiamen City, Fujian, China.
⁴ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China.
⁵ Clinical Laboratory, Guankou Hospital, Jimei District, Xiamen City, Fujian, China.

Abstract

Background: The aim of this study is to evaluate the level and role of serum irisin in elderly patients with type 2 diabetes mellitus (T2DM) using case-control study.

Methods: A total of 71 patients with T2DM were selected as the case group according to the inclusion criteria and exclusion criteria; and the ratio of 1:1 was calculated according to the inclusion rate of the residents. The cohort established in Guankou Town, Jimei District, Xiamen City, Fujian Province, China and the residents of this cohort were selected at the age of 60 and above. A total of 71 healthy subjects were included as the control group with the same gender and the age with a difference of ± 5 years old. The clinical data of the subjects were collected to determine their previous history, blood pressure, body mass index (BMI), hemoglobin (HB), liver function test, renal function test, fasting blood glucose and serum lipid. The irisin level in serum was measured by enzyme-linked immunosorbent assay (ELISA). The data were analyzed by using SPSS17.0 software. Single factor analysis using Chi-square test or t-test was performed to compare the differences between T2DM patients with the control group of the general data, clinical indicators and irisin level in serum. Logistic regression was used to analyze the protective factors and risk factors of diabetes mellitus.

Results: The results of single factor analysis showed that the level of irisin in T2DM group was significantly lower than that in the control group (703.37 ± 241.51 ng/mL and 800.22 ± 275.59 ng/mL, respectively). The levels of BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG) and fasting plasma glucose (FPG) in T2DM group were higher than those in control group, and differences were statistically significant. Logistic regression analysis indicated that irisin may be a protective factor for type 2 diabetes (odds ratio (OR) = 0.997, 95% confidence interval (CI): 0.994 - 0.999).

Conclusions: The serum irisin level in T2DM group was significantly lower than that in control group, suggesting that irisin may be a protective factor for type 2 diabetes.

Keywords: Elderly; Irisin; Type 2 diabetes mellitus.