Review of the Biomolecular Modification of the Metal-Organ-Framework

Qiqi Xing; Yixiao Pan; Yihe Hu; Long Wang

doi:10.3389/fchem.2020.00642

Review of the Biomolecular Modification of the Metal-Organ-Framework

Front Chem. 2020 Jul 28:8:642. doi: 10.3389/fchem.2020.00642. eCollection 2020.

Authors

Qiqi Xing¹, Yixiao Pan¹, Yihe Hu¹, Long Wang¹

Affiliation

¹ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Metal-organ frameworks (MOFs), as a kind of novel artificial material, have been widely studied in the field of chemistry. MOFs are capable of high loading capacities, controlled release, plasticity, and biosafety because of their porous structure and have been gradually functionalized as a drug carrier. Recently, a completely new strategy of combining biomolecules, such as oligonucleotides, polypeptides, and nucleic acids, with MOF nanoparticles was proposed. The synthetic bio-MOFs conferred strong protection and endowed the MOFs with particular biological functions. Biomolecular modification of MOFs to form bridges for communication between different subjects has received increased attention. This review will focus on bio-MOFs modification methods and discuss the advantages, applications, prospects, and challenges of using MOFs in the field of biomolecule delivery.

Keywords: MOF; biomolecular; delivery; modification; nano material.

Publication types

Review