Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy

Yanfei Yang; Yang Yang; Jing Yang; Xia Zhao; Xiawei Wei

doi:10.3389/fcell.2020.00758

Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy

Front Cell Dev Biol. 2020 Aug 11:8:758. doi: 10.3389/fcell.2020.00758. eCollection 2020.

Authors

Yanfei Yang¹, Yang Yang¹, Jing Yang², Xia Zhao¹, Xiawei Wei²

Affiliations

¹ Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China.
² Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Ovarian cancer is one of the leading causes of death in patients with gynecological malignancy. Despite optimal cytoreductive surgery and platinum-based chemotherapy, ovarian cancer disseminates and relapses frequently, with poor prognosis. Hence, it is urgent to find new targeted therapies for ovarian cancer. Recently, the tumor microenvironment has been reported to play a vital role in the tumorigenesis of ovarian cancer, especially with discoveries from genome-, transcriptome- and proteome-wide studies; thus tumor microenvironment may present potential therapeutic target for ovarian cancer. Here, we review the interactions between the tumor microenvironment and ovarian cancer and various therapies targeting the tumor environment.

Keywords: anti-angiogenesis therapy; immune checkpoint inhibitors; ovarian cancer; tumor microenvironment; tumor-associated macrophage-targeted strategies.

Publication types

Review