Systematic literature review of clinical outcomes in adults with metastatic or advanced synovial sarcoma

Future Oncol. 2020 Dec;16(35):2997-3013. doi: 10.2217/fon-2020-0575. Epub 2020 Aug 27.


Background: Synovial sarcoma (SS) is a rare, aggressive soft tissue sarcoma with a poor prognosis after metastasis. The objective of this study was to conduct a systematic review of the clinical evidence for therapeutic options for adults with metastatic or advanced SS. Materials & methods: Relevant databases were searched with predefined keywords. Results: Thirty-nine publications reported clinical data for systemic treatment and other interventions. Data on survival outcomes varied but were generally poor (progression-free survival: 1.0-7.7 months; overall survival: 6.7-29.2 months) for adults with metastatic and advanced SS. A high frequency of neutropenia with systemic treatment and low quality of life post-progression were reported. Conclusion: Reported evidence suggests poor outcomes in adults with metastatic and advanced SS and the need for the development of new treatment modalities.

Keywords: best supportive care; metastasis; quality of life; response; safety; surgical intervention; survival; synovial sarcoma; systematic review; systemic treatment.

Publication types

  • Systematic Review

MeSH terms

  • Adult
  • Humans
  • Neoplasm Metastasis
  • Quality of Life
  • Sarcoma, Synovial / mortality
  • Sarcoma, Synovial / pathology
  • Sarcoma, Synovial / psychology
  • Sarcoma, Synovial / therapy*