Clinical outcomes of His-Purkinje conduction system pacing

Pacing Clin Electrophysiol. 2021 Jan;44(1):5-14. doi: 10.1111/pace.14050. Epub 2020 Sep 7.

Abstract

His-Purkinje conduction system pacing (HPCSP) in the form of His bundle pacing (HBP) and left bundle branch pacing (LBBP) allows normal left ventricular activation, thereby preventing the adverse consequences of right ventricular pacing. HBP has been established for several years with centers from China, Europe, and North America reporting their experience. There is international guidance as to how to implant such systems with the differing patterns of His bundle capture clearly described. LBBP is a more recent innovation with potential advantages including improved pacing parameters. HPCSP has been extensively studied in a variety of indications including cardiac resynchronization therapy, atrioventricular node ablation, and bradycardia pacing. This review will focus on the clinical outcomes of HPCSP including mortality and morbidity of heart failure hospitalization and symptoms.

Keywords: His bundle pacing; cardiac resynchronization therapy; clinical outcomes; left bundle branch pacing.

Publication types

  • Review

MeSH terms

  • Bradycardia / physiopathology
  • Bradycardia / therapy*
  • Bundle of His / physiopathology*
  • Bundle-Branch Block / physiopathology
  • Bundle-Branch Block / therapy*
  • Cardiac Conduction System Disease / physiopathology
  • Cardiac Conduction System Disease / therapy*
  • Cardiac Pacing, Artificial*
  • Cardiac Resynchronization Therapy
  • Heart Conduction System / physiopathology
  • Humans
  • Purkinje Fibers / physiopathology