Basic Histopathologic Assessment of Germ Cell Tumors for Clinic and Research

Methods Mol Biol. 2021:2195:1-11. doi: 10.1007/978-1-0716-0860-9_1.

Abstract

This chapter introduces the macroscopic and light microscopic features of testicular germ cell tumors (GCT) commonly encountered in clinical practice. Accurate diagnosis of these histologically diverse neoplasms is essential not only for clinical management but also for serving as the basis for interpretation of research findings. We will focus on general histopathologic concepts and discuss the use of immunohistochemistry (IHC) as an aid to the diagnosis.

Keywords: Germ cell tumor; Immunohistochemistry.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Biopsy
  • Carcinoma in Situ
  • Clinical Decision-Making
  • Diagnosis, Differential
  • Disease Management
  • Female
  • Humans
  • Immunohistochemistry / methods
  • Male
  • Microscopy / methods
  • Neoplasm Grading* / methods
  • Neoplasm Staging* / methods
  • Neoplasms, Germ Cell and Embryonal / diagnosis*
  • Research
  • Testicular Neoplasms / diagnosis

Substances

  • Biomarkers, Tumor

Supplementary concepts

  • Testicular Germ Cell Tumor