Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19

J Infect. 2020 Dec;81(6):e4-e6. doi: 10.1016/j.jinf.2020.08.029. Epub 2020 Aug 25.


Objective: To assess post-discharge persistent symptoms and health-related quality of life (HRQoL) of patients hospitalized in a COVID-19 ward unit more than 100 days after their admission.

Methods: All eligible patients were contacted by phone by trained physicians and were asked to answer to a dedicated questionnaire. Patients managed in hospital ward without needing intensive care were compared with those who were transferred in intensive care units (ICU).

Results: We included 120 patients after a mean (±SD) of 110.9 (±11.1) days following admission. The most frequently reported persistent symptoms were fatigue (55%), dyspnoea (42%), loss of memory (34%), concentration and sleep disorders (28% and 30.8%, respectively). Comparisons between ward- and ICU patients led to no statistically significant differences regarding those symptoms. In both group, EQ-5D (mobility, self-care, pain, anxiety or depression, usual activity) was altered with a slight difference in pain in the ICU group.

Conclusion: Most patients requiring hospitalization for COVID-19 still have persistent symptoms. While there were few differences between HRQoL between ward and ICU patients, our findings must be confirmed in larger cohorts, including more severe patients.

Keywords: Covid-19; Health-related quality of life; Persistent symptoms.

Publication types

  • Letter

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anxiety / epidemiology
  • COVID-19 / epidemiology*
  • Fatigue / epidemiology
  • Female
  • Hospitalization*
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Pain / epidemiology
  • Patient Discharge*
  • Quality of Life*
  • SARS-CoV-2
  • Surveys and Questionnaires