In vitro corrosion resistance and cytocompatibility of Mg66Zn28Ca6 amorphous alloy materials coated with a double-layered nHA and PCL/nHA coating

Abstract

In this study, the double-layered nHA and PCL/nHA coatings were prepared on the substrate of Mg₆₆Zn₂₈Ca₆ amorphous alloy. The phase composition and morphological were analyzed by Scanning electron microscopy, Energy dispersive spectrometry and X-ray diffraction. The electrochemical properties of these samples were measured on electrochemical workstation. The degradation rate was evaluated by measuring the pH value and weight loss. Experiment results show that the outer composite PCL/nHA coating is a porous structure, where the porosity and pore size could be easily controlled by adding nHA. The combined properties of double-layered nHA and PCL/nHA coating can control the degradation of the Mg₆₆Zn₂₈Ca₆ amorphous alloy in the scheduled time. Moreover,the cell co-culture and cell adhesion tests show that the double-layered nHA and PCL/2%nHA coating possesses the best cytocompatibility with cell organization. The above experiments have demonstrated that the Mg₆₆Zn₂₈Ca₆ amorphous alloy which was coated with PCL/nHA composite coating have good mechanical properties, good corrosion resistance and perfect cytocompatibility. It can be used as a potential novel biomaterial for bone tissue engineering.

Keywords: Biodegradable; Corrosion resistance; Cytocompatibility; Double-layers; PCL/nHA.