Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications

Polymers (Basel). 2020 Aug 25;12(9):1915. doi: 10.3390/polym12091915.


We report in this paper the synthesis and characterization of a new collagen-based material. This material was obtained in a spongy form and was functionalized with an antibiotic, ciprofloxacin. The targeted applications of these kind of materials concern the post-operative prophylaxis. The in vitro tests (antimicrobial, cytotoxic, drug release) showed that sponges with a concentration of 0.75 g of ciprofloxacin per gram of collagen could be beneficial for the desired applications.

Keywords: ciprofloxacin; collagen-based materials; cytotoxicity; drug release.