The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

Nat Immunol. 2020 Oct;21(10):1146-1151. doi: 10.1038/s41590-020-0779-1.

Authors

Maja Buszko¹, Jung-Hyun Park², Daniela Verthelyi³, Ranjan Sen⁴, Howard A Young⁵, Amy S Rosenberg⁶

Affiliations

¹ Cellular Immunology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
² Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
³ Laboratory of Innate Immunity, Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
⁴ Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA.
⁵ Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, USA.
⁶ Laboratory of Immunology, Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. amy.rosenberg@fda.hhs.gov.

PMID: 32855555
DOI: 10.1038/s41590-020-0779-1

No abstract available

MeSH terms

Angioedema / blood
Angioedema / immunology*
Angioedema / pathology
Angioedema / virology
Angiotensin-Converting Enzyme 2
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Antiviral Agents / therapeutic use
Betacoronavirus / immunology*
Biomarkers / blood
COVID-19
COVID-19 Drug Treatment
COVID-19 Testing
Clinical Laboratory Techniques / methods
Congresses as Topic
Coronavirus Infections / blood
Coronavirus Infections / diagnosis
Coronavirus Infections / drug therapy
Coronavirus Infections / epidemiology
Coronavirus Infections / immunology*
Cytokine Release Syndrome / blood
Cytokine Release Syndrome / immunology*
Cytokine Release Syndrome / virology
Cytokines / antagonists & inhibitors
Cytokines / blood
Cytokines / immunology
Cytokines / metabolism*
Humans
Internet
Kallikrein-Kinin System / drug effects
Kallikrein-Kinin System / immunology
Pandemics
Peptidyl-Dipeptidase A / metabolism
Pneumonia, Viral / blood
Pneumonia, Viral / diagnosis
Pneumonia, Viral / epidemiology
Pneumonia, Viral / immunology*
Pulmonary Alveoli / immunology
Pulmonary Alveoli / pathology
SARS-CoV-2
Severity of Illness Index
Signal Transduction / drug effects
Signal Transduction / immunology
Spike Glycoprotein, Coronavirus / immunology
Spike Glycoprotein, Coronavirus / metabolism
Time Factors
Time-to-Treatment

Substances

Anti-Inflammatory Agents
Antiviral Agents
Biomarkers
Cytokines
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2