Mitophagy is induced by short ubiquitin chains on mitochondria

J Cell Biol. 2020 Sep 7;219(9):e202008031. doi: 10.1083/jcb.202008031.

Abstract

Mitophagy has a critical role in maintaining cellular homeostasis by removing damaged mitochondria. In this issue, Yamano et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912144) uncover that a novel complex of the autophagy adaptor optineurin and the membrane protein ATG9A specifically regulate ubiquitin-induced mitophagy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Autophagy
  • Autophagy-Related Proteins / genetics
  • Autophagy-Related Proteins / metabolism
  • HeLa Cells
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Mitochondria / metabolism
  • Mitophagy*
  • Ubiquitin* / metabolism
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism
  • Ubiquitination
  • Vesicular Transport Proteins / metabolism

Substances

  • ATG9A protein, human
  • Autophagy-Related Proteins
  • Membrane Proteins
  • Ubiquitin
  • Vesicular Transport Proteins
  • Ubiquitin-Protein Ligases