Transcending the impenetrable: how proteins come to terms with membranes

Biochim Biophys Acta. 1988 Jun 9;947(2):307-33. doi: 10.1016/0304-4157(88)90013-5.

Abstract

In the living cell, proteins are efficiently sorted to a whole range of subcellular compartments. In many cases, sorting specificity is mediated by short 'sorting signals' attached either permanently or transiently to the protein. At long last, a fairly coherent picture of the design and function of many such sorting signals is beginning to emerge.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Cell Compartmentation*
  • Cell Membrane / metabolism*
  • Lipid Bilayers / metabolism
  • Membrane Lipids / metabolism
  • Models, Biological
  • Models, Molecular
  • Protein Sorting Signals / physiology
  • Proteins / metabolism*

Substances

  • Lipid Bilayers
  • Membrane Lipids
  • Protein Sorting Signals
  • Proteins