Photo-electrochemical detection of dopamine in human urine and calf serum based on MIL-101 (Cr)/carbon black

Mikrochim Acta. 2020 Aug 28;187(9):526. doi: 10.1007/s00604-020-04524-z.

Abstract

A new photo-electrochemical sensor based on MIL-101(Cr) MOF/carbon black (CB) is fabricated and characterized. By using differential pulse voltammetry, dopamine (DA) can be effectively detected using a photo-electrochemical MIL-101(Cr)/CB sensor under visible light. The CB acts as the electron bridge to combine with the large specific surface area and photo-catalytic feature of MOF, which contribute to the improvements of sensitivity of DA detection. The concentration of the catalyst, pH value, accumulation potential, and accumulation time were also optimized. Furthermore, the electrochemical performances of MIL-101(Cr)/CB sensor was investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scan rate, electrochemically active surface area (ECSA), and amperometric responses. A detection limit of 0.38 nM (LOD = 3 sb/S, sb = 0.028) and a working range of 1 nM to 2.22 μM has been achieved. The MIL-101(Cr)/CB sensor exhibits excellent reproducibility, stability, and selectivity and also has satisfactory recovery rate for the analysis of real samples including calf serum and human urine. Graphical abstract.

Keywords: Carbon black; Dopamine; Metal-organic frameworks; Photo-electrochemical detection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalysis / radiation effects
  • Cattle
  • Dopamine / blood*
  • Dopamine / urine*
  • Electrochemical Techniques / instrumentation
  • Electrochemical Techniques / methods*
  • Electrodes
  • Humans
  • Light
  • Limit of Detection
  • Metal-Organic Frameworks / chemistry*
  • Metal-Organic Frameworks / radiation effects
  • Photochemical Processes
  • Reproducibility of Results
  • Soot / chemistry*

Substances

  • MIL-101
  • Metal-Organic Frameworks
  • Soot
  • Dopamine