Exploring the association of predisposing factors of Cerebral Palsy and developmental defects of enamel: a case-control study

Eur Arch Paediatr Dent. 2021 Jun;22(3):367-374. doi: 10.1007/s40368-020-00558-2. Epub 2020 Aug 29.

Abstract

Aim: To evaluate the occurrence of developmental defects of enamel (DDE) in children and adolescents with Cerebral Palsy (CP) and to analyze the effect of common factors in the etiology of CP on the occurrence of DDE.

Methods: A case-control study was carried out using the modified DDE index to classify enamel defects. The study group (SG) consisted of 45 participants with CP aged between three and 14 years. The control group (CG) consisted of 88 normotypical schoolchildren, paired by gender and age group. Caregivers answered a questionnaire on their socioeconomic status and medical history. The Chi-square tests, bivariate and multivariate analysis were performed (level significance < 0.05).

Results: The occurrence of DDE in SG and CG was 60% and 64.8%, respectively (p value = 0.726). The most frequent defect observed in SG was diffuse opacity (44.4%), followed by demarcated opacity (26.7%) and enamel hypoplasia (2.2%). No difference was observed in the defect's distribution among both groups (p value = 0.083). For SG, the bivariate analysis revealed a statically significant association between the presence of DDE and age group 7-14 years old and maternal schooling below 11 years. After adjusting for confounding variables, age, family income and maternal schooling were not associated with DDE.

Conclusion: In conclusion, the occurrence of DDE was high and similar in both groups. The pre, peri or post-natal factors associated with CP were not significant for the presence of DDE.

Keywords: Associated factors; Cerebral palsy; Developmental defects of enamel.

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Causality
  • Cerebral Palsy* / epidemiology
  • Cerebral Palsy* / etiology
  • Child
  • Child, Preschool
  • Dental Enamel
  • Dental Enamel Hypoplasia* / epidemiology
  • Dental Enamel Hypoplasia* / etiology
  • Humans
  • Prevalence