Trisomy 21 and Coronavirus Disease 2019 in Pediatric Patients

J Pediatr. 2021 Jan:228:294-296. doi: 10.1016/j.jpeds.2020.08.067. Epub 2020 Aug 27.

Abstract

We present 4 pediatric patients with trisomy 21 (T21) and associated comorbidities who developed coronavirus disease 2019 requiring hospitalization. A review of the literature revealed that comorbidities associated with T21 may predispose patients to severe disease. Children with T21 should be considered high risk and monitored carefully if infected with severe acute respiratory syndrome coronavirus 2.

Keywords: COVID-19; Down syndrome; trisomy 21.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • COVID-19 / complications*
  • COVID-19 / epidemiology*
  • Comorbidity*
  • Disease Susceptibility*
  • Down Syndrome / complications*
  • Down Syndrome / epidemiology*
  • Hospitalization
  • Humans
  • Infant
  • Male
  • Risk Factors
  • SARS-CoV-2