Laryngopharyngeal Reflux in Hypertrophic Laryngeal Diseases

Ear Nose Throat J. 2022 May;101(4):NP158-NP163. doi: 10.1177/0145561320953232. Epub 2020 Aug 31.


Objectives: To evaluate the characteristics of laryngopharyngeal reflux (LPR) in patients with different hypertrophic laryngeal diseases and to explore the relationship between LPR and these diseases.

Methods: A retrospective analysis was performed. The clinical data of 154 patients were collected. According to their diagnoses, patients were divided into 3 groups. Group 1 included 49 patients with vocal cord polyps. Group 2 contained 52 patients with vocal cord leukoplakia. Group 3 included 53 patients with laryngeal carcinoma. The reflux symptom indexes (RSIs), reflux finding scores (RFSs), and Ryan scores of all patients were evaluated and compared.

Results: Patients with vocal cord polyps were the youngest of the 3 groups, and those with laryngeal carcinoma were the oldest. A male preponderance emerged in each group. In total, 128 patients (83.12%) had positive RSI/RFS values and 60 (60/146, 41.1%) patients had positive Ryan scores. The positive RSI/RFS rates of both groups 1 and 2 (89.80% and 92.16%, respectively) were significantly higher than that of group 3 (69.81%). Moreover, the positive Ryan score rates in both groups 1 and 2 (39.58% and 53.85%, respectively) were significantly higher than that of group 3 (28.26%).

Conclusions: Laryngopharyngeal reflux occurs in many patients with vocal cord polyps, vocal cord leukoplakia, and vocal cord carcinoma, indicating that LPR may be important in the pathogenesis of these diseases. Laryngopharyngeal reflux occurs more common in patients with vocal cord polyps and leukoplakia and less common in those with laryngeal carcinoma, suggesting the role of LPR on these diseases may be different.

Keywords: PH monitoring; laryngopharyngeal reflux; reflux finding score; reflux symptoms index.

MeSH terms

  • Carcinoma* / pathology
  • Humans
  • Laryngeal Diseases* / pathology
  • Laryngeal Neoplasms* / pathology
  • Laryngopharyngeal Reflux* / complications
  • Leukoplakia / etiology
  • Leukoplakia / pathology
  • Male
  • Polyps* / complications
  • Polyps* / pathology
  • Retrospective Studies
  • Vocal Cords / pathology