Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3- e][1,2,4]triazine Derivatives

Molecules. 2020 Aug 29;25(17):3948. doi: 10.3390/molecules25173948.

Abstract

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.

Keywords: 1,2,4-triazine; anticancer activity; fluviols; fused tetrazole derivatives; pyrazolo[4,3-e][1,2,4]triazines; sulfonamides.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Pyrazoles* / chemical synthesis
  • Pyrazoles* / pharmacokinetics
  • Structure-Activity Relationship
  • Sulfonamides* / chemical synthesis
  • Sulfonamides* / pharmacology
  • Triazines* / chemical synthesis
  • Triazines* / pharmacology

Substances

  • Antineoplastic Agents
  • Pyrazoles
  • Sulfonamides
  • Triazines