Longitudinal observation of solitary fibrous tumor translation into malignant pulmonary artery intimal sarcoma

J Cardiothorac Surg. 2020 Sep 1;15(1):233. doi: 10.1186/s13019-020-01271-3.


Background: Pulmonary artery intimal sarcoma (PAIS) is a rare malignant tumor that was usually misdiagnosed as chronic pulmonary thromboembolism.

Case presentation: We previously reported a solitary fibrous tumor in the pulmonary artery presented with acute pulmonary embolism, which was identified by 99mTc-Galacto-RGD2 imaging. However, this patient had a recurrence in situ two-year after surgery, post-operative pathology revealed pulmonary artery intimal sarcoma. At one-year post-operation, 18F-FDG PET/CT was performed for exclusion of tumor metastasis, which showed FDG avid lesion in the T5, T10, and L5 vertebral bodies, as well as in bilateral ilium and right ischium.

Conclusions: This is the first longitudinal observation of a solitary fibrous tumor (SFT) development into a pulmonary artery intimal sarcoma (PAIS) and presented with multiple bone metastases.

Keywords: 18F-FDG; Malignant potential; Positron emission tomography; Pulmonary artery intimal sarcoma; Solitary fibrous tumor.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / secondary*
  • Cell Transformation, Neoplastic
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Positron Emission Tomography Computed Tomography
  • Pulmonary Artery
  • Sarcoma / pathology*
  • Sarcoma / surgery
  • Solitary Fibrous Tumors / pathology*
  • Solitary Fibrous Tumors / surgery
  • Tunica Intima
  • Vascular Neoplasms / pathology*


  • Fluorodeoxyglucose F18