Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy

Indian J Pharmacol. 2020 May-Jun;52(3):213-215. doi: 10.4103/ijp.IJP_370_19. Epub 2020 Aug 4.


We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the discontinuation of the duloxetine.

Keywords: Duloxetine; hypertensive urgency; painful diabetic neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Analgesics / adverse effects*
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / drug effects*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetic Neuropathies / diagnosis
  • Diabetic Neuropathies / drug therapy*
  • Diabetic Neuropathies / etiology
  • Duloxetine Hydrochloride / adverse effects*
  • Female
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / diagnosis
  • Hypertension / drug therapy
  • Hypertension / physiopathology
  • Middle Aged
  • Treatment Outcome


  • Analgesics
  • Antihypertensive Agents
  • Duloxetine Hydrochloride