Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

doi:10.1002/adhm.202000681

Review

. 2020 Sep 2:e2000681.

doi: 10.1002/adhm.202000681. Online ahead of print.

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Na Xu¹, Jijiang Fu¹, Lingzhou Zhao², Paul K Chu³, Kaifu Huo^{1

4}

Affiliations

¹ The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430081, China.
² State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
³ Department of Physics, Department of Materials Science and Engineering and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
⁴ Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China.

PMID: 32875743
DOI: 10.1002/adhm.202000681

Review

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Na Xu et al. Adv Healthc Mater. 2020.

. 2020 Sep 2:e2000681.

doi: 10.1002/adhm.202000681. Online ahead of print.

Authors

Na Xu¹, Jijiang Fu¹, Lingzhou Zhao², Paul K Chu³, Kaifu Huo^{1

4}

Affiliations

¹ The State Key Laboratory of Refractories and Metallurgy, Institute of Advanced Materials and Nanotechnology, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430081, China.
² State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
³ Department of Physics, Department of Materials Science and Engineering and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
⁴ Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China.

PMID: 32875743
DOI: 10.1002/adhm.202000681

Abstract

Bone fracture is prevalent among athletes and senior citizens and may require surgical insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to its high corrosion resistance, good biocompatibility, and modulus compatible with natural bone tissues. However, bone repair and regrowth are impeded by the insufficient intrinsic osteogenetic capability of Ti and Ti alloys and potential bacterial infection. The physicochemical properties of the materials and nano/microstructures on the implant surface are crucial for clinical success and loading with biofunctional elements such as Sr, Zn, Cu, Si, and Ag into nano/microstructured TiO₂ coating has been demonstrated to enhance bone repair/regeneration and bacterial resistance of Ti implants. In this review, recent advances in biofunctional element-incorporated nano/microstructured coatings on Ti and Ti alloy implants are described and the prospects and limitations are discussed.

Keywords: antibacterial performances; biofunctional elements; bone implants; osteogenic activities; titanium and titanium alloys.

PubMed Disclaimer

Cited by

Incorporating zinc ion into titanium surface promotes osteogenesis and osteointegration in implantation early phase.
Tian X, Zhang P, Xu J. Tian X, et al. J Mater Sci Mater Med. 2023 Nov 2;34(11):55. doi: 10.1007/s10856-023-06751-1. J Mater Sci Mater Med. 2023. PMID: 37917203 Free PMC article.
The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces.
Han J, Ma Q, An Y, Wu F, Zhao Y, Wu G, Wang J. Han J, et al. J Nanobiotechnology. 2023 Aug 19;21(1):277. doi: 10.1186/s12951-023-02017-8. J Nanobiotechnology. 2023. PMID: 37596638 Free PMC article. Review.
Bone tissue engineering for treating osteonecrosis of the femoral head.
Bian Y, Hu T, Lv Z, Xu Y, Wang Y, Wang H, Zhu W, Feng B, Liang R, Tan C, Weng X. Bian Y, et al. Exploration (Beijing). 2023 Feb 28;3(2):20210105. doi: 10.1002/EXP.20210105. eCollection 2023 Apr. Exploration (Beijing). 2023. PMID: 37324030 Free PMC article. Review.
Recent advances on nanomaterials for antibacterial treatment of oral diseases.
Chen Z, Chu Z, Jiang Y, Xu L, Qian H, Wang Y, Wang W. Chen Z, et al. Mater Today Bio. 2023 Apr 15;20:100635. doi: 10.1016/j.mtbio.2023.100635. eCollection 2023 Jun. Mater Today Bio. 2023. PMID: 37143614 Free PMC article. Review.
Functional chitosan gel coating enhances antimicrobial properties and osteogenesis of titanium alloy under persistent chronic inflammation.
Zhang T, Qin X, Gao Y, Kong D, Jiang Y, Cui X, Guo M, Chen J, Chang F, Zhang M, Li J, Yin P. Zhang T, et al. Front Bioeng Biotechnol. 2023 Feb 15;11:1118487. doi: 10.3389/fbioe.2023.1118487. eCollection 2023. Front Bioeng Biotechnol. 2023. PMID: 36873358 Free PMC article.

See all "Cited by" articles

References

1. M. B. Guglielmotti, D. G. Olmedo, R. L. Cabrini, Periodontology 2000 2019, 79, 178.
1. V. Martin, A. Bettencourt, Mater. Sci. Eng., C 2018, 82, 363.
1. R. Quarto, P. Giannoni, Methods Mol. Biol. 2016, 1416, 21.
1. S. Maher, A. Mazinani, M. R. Barati, D. Losic, Expert Opin. Drug Delivery 2018, 15, 1021.
1. D. Lopes, C. Martins-Cruz, M. B. Oliveira, J. F. Mano, Biomaterials 2018, 185, 240.

Publication types

Actions

Grants and funding

CityU 11205617/General Research Funds

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Research Materials
- NCI CPTC Antibody Characterization Program

[1] M. B. Guglielmotti, D. G. Olmedo, R. L. Cabrini, Periodontology 2000 2019, 79, 178.

[2] M. B. Guglielmotti, D. G. Olmedo, R. L. Cabrini, Periodontology 2000 2019, 79, 178.

[3] V. Martin, A. Bettencourt, Mater. Sci. Eng., C 2018, 82, 363.

[4] V. Martin, A. Bettencourt, Mater. Sci. Eng., C 2018, 82, 363.

[5] R. Quarto, P. Giannoni, Methods Mol. Biol. 2016, 1416, 21.

[6] R. Quarto, P. Giannoni, Methods Mol. Biol. 2016, 1416, 21.

[7] S. Maher, A. Mazinani, M. R. Barati, D. Losic, Expert Opin. Drug Delivery 2018, 15, 1021.

[8] S. Maher, A. Mazinani, M. R. Barati, D. Losic, Expert Opin. Drug Delivery 2018, 15, 1021.

[9] D. Lopes, C. Martins-Cruz, M. B. Oliveira, J. F. Mano, Biomaterials 2018, 185, 240.

[10] D. Lopes, C. Martins-Cruz, M. B. Oliveira, J. F. Mano, Biomaterials 2018, 185, 240.

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Affiliations

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources

Research Materials