Distribution of cyclosporin A between blood cells and plasma of cardiac and renal transplant recipients

Ther Drug Monit. 1988;10(1):28-33.


The relationship between blood cells and plasma concentrations of cyclosporin A (Cy A) determined by radioimmunoassay, was investigated in 12 heart and 12 kidney transplant recipients. The decision between a linear and nonlinear model was made according to a standardized residuals plot. We observed high blood cells-plasma concentration ratios in the two groups, indicating a high affinity of Cy A for blood cells. The distribution of Cy A between blood cells and plasma was ascribed to a nonlinear saturable model in the two groups. According to our results we have simulated the blood-plasma concentration ratio of Cy A as a function of plasma Cy A concentration and hematocrit.

MeSH terms

  • Adolescent
  • Adult
  • Blood Cells / analysis*
  • Cyclosporins / blood*
  • Female
  • Heart Transplantation*
  • Humans
  • Kidney Transplantation*
  • Male
  • Mathematics
  • Middle Aged
  • Plasma / analysis*


  • Cyclosporins