Clinical Analysis of Laryngeal Spindle Cell Carcinoma

ORL J Otorhinolaryngol Relat Spec. 2020;82(6):310-317. doi: 10.1159/000508134. Epub 2020 Sep 2.

Abstract

Aims: To investigate the clinical features, treatment, and outcomes of laryngeal spindle cell carcinoma (SpCC).

Methods: Between 2005 and 2014, patients from our hospital with SpCC of the larynx were retrospectively analyzed alongside patient data from the SEER database of America.

Results: A total of 11 patients with SpCC of the larynx were diagnosed and underwent surgery in our hospital. All patients were male and all tumors were located in the glottis. The 3- and 5-year OS rates were both 54.5%. In the SEER database, 148 patients were diagnosed with SpCC of the larynx. The 3- and 5-year OS rates were 72.8 and 63.2%, respectively. According to the comparison of propensity score-matched analysis, the OS was longer in squamous cell carcinoma (SCC) of the larynx (p < 0.0001).

Conclusion: SpCC of the larynx is rare and typically originates in the glottis. Its prognosis is worse than that of laryngeal SCC, and surgery is a reasonable treatment strategy.

Keywords: Clinical protocols; Immunohistochemistry; Laryngeal neoplasm; Spindle cell carcinoma.

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / surgery*
  • Glottis / pathology
  • Glottis / surgery*
  • Head and Neck Neoplasms
  • Humans
  • Laryngeal Neoplasms / diagnosis
  • Laryngeal Neoplasms / mortality
  • Laryngeal Neoplasms / surgery*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Squamous Cell Carcinoma of Head and Neck
  • Survival Rate