Vitamin B1 Intake in Multiple Sclerosis Patients and its Impact on Depression Presence: A Pilot Study

Nutrients. 2020 Aug 31;12(9):2655. doi: 10.3390/nu12092655.


Vitamin B1, or thiamine, is one of the most relevant vitamins in obtaining energy for the nervous system. Thiamine deficiency or lack of activity causes neurological manifestations, especially symptoms of depression, intrinsic to multiple sclerosis (MS) and related to its pathogenesis. On this basis, the aim of this study was to determine the possible relationship between the nutritional habits of patients with MS and the presence of depression. Therefore, a cross-sectional and observational descriptive study was conducted. An analysis of dietary habits and vitamin B1 consumption in a Spanish population of 51 MS patients was performed by recording the frequency of food consumption. Results showed a vitamin B1 intake within the established range, mainly provided by the consumption of ultra-processed products such as cold meats or pastries, and a total carbohydrate consumption lower than recommended, which stands out for its high content of simple carbohydrates deriving from processed foods such as dairy desserts, juice, snacks, pastries, chocolate bars, soft drinks and fermented alcohol. In addition, a significant negative correlation between depression and the intake of thiamine and total carbohydrates was observed. These findings could explain the influence of MS patients' eating habits, and consequently vitamin B1 activity, on depression levels.

Keywords: depression; multiple sclerosis; vitamin B1.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Depression / diet therapy*
  • Diet
  • Dietary Carbohydrates / administration & dosage
  • Dietary Supplements
  • Fast Foods / analysis
  • Female
  • Food Handling
  • Health Behavior
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / diet therapy*
  • Nutritional Status
  • Pilot Projects
  • Snacks
  • Thiamine / administration & dosage*


  • Dietary Carbohydrates
  • Thiamine