Adherence to the MIND diet is associated with 12-year all-cause mortality in older adults

Public Health Nutr. 2022 Feb;25(2):358-367. doi: 10.1017/S1368980020002979. Epub 2020 Sep 3.


Objective: To prospectively evaluate the association of three dietary patterns: the MIND (Mediterranean-DASH diet intervention for Neurodegenerative Delay) diet; a Mediterranean-type diet and a traditional diet, with all-cause mortality over a 12-year period in an older sample.

Design: A longitudinal birth cohort study. We ascertained dietary patterns using FFQ data at baseline (2004-2007) and mortality using linkage data. Cox regression was used to estimate mortality hazard ratios (HR) with adjustment for confounders.

Setting: The Lothian Birth Cohort 1936 (LBC1936) study in Edinburgh, Scotland.

Participants: Dietary patterns were ascertained in 882 participants, mean age 69·5 (±0·8) years, at baseline. During the 12-year follow-up (to October 2019), 206 deaths occurred.

Results: In the basic-adjusted model, all three dietary patterns were significantly associated with mortality, the MIND diet and Mediterranean-type diet with a lower risk and the traditional diet with a higher risk. In fully adjusted models, MIND diet score was inversely related to all-cause mortality (HR 0·88; 95 % CI 0·79, 0·97) such that the risk of death was reduced by 12 % per unit increase in MIND diet score. Participants in the top compared with the bottom third of MIND diet score had a 37 % lower risk of death (HR 0·63; 95 % CI 0·41, 0·96). No significant associations with the Mediterranean-type or traditional dietary patterns were observed in the final multivariate model.

Conclusions: Our findings suggest that closer adherence to the MIND diet is associated with a significantly lower risk of all-cause mortality, over 12 years of follow-up, and may constitute a valid public health recommendation for prolonged survival.

Keywords: Dietary patterns; MIND diet; Mediterranean diet; Mortality; Older adults.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cohort Studies
  • Diet, Mediterranean*
  • Dietary Approaches To Stop Hypertension*
  • Humans
  • Proportional Hazards Models
  • Scotland / epidemiology