Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 3;324(15):1565-1567.
doi: 10.1001/jama.2020.17052. Online ahead of print.

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Matthijs Kox  1 , Nicole J B Waalders  1 , Emma J Kooistra  1 , Jelle Gerretsen  1 , Peter Pickkers  1
Affiliations

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

Matthijs Kox et al. JAMA. .

Abstract

This study compares levels of tumor necrosis factor α, IL-6, and IL-8 in critically ill patients with coronavirus disease 2019 (COVID-19) vs those with other critical illness to better characterize the contribution of cytokine storm to COVID-19 pathophysiology.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Cytokine Levels in Critically Ill Patients With Coronavirus Disease 2019 (COVID-19) and Other Conditions
Plasma concentrations of tumor necrosis factor (TNF) (A), IL-6 (B), and IL-8 (C) in patients with COVID-19 and acute respiratory distress syndrome (ARDS) (n = 46), septic shock with ARDS (n = 51), septic shock without ARDS (n = 15), out-of-hospital cardiac arrest (OHCA; n = 30), and multiple traumas (n = 62). Data are presented as scatter plots with red horizontal bars indicating the geometric mean levels. aP < .01 vs COVID-19 with ARDS. bP < .001 vs COVID-19 with ARDS. cP < .05 vs COVID-19 with ARDS.
See this image and copyright information in PMC

Comment in

  • doi: 10.1001/jamainternmed.2020.3313

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, Katze MG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76(1):16-32. doi:10.1128/MMBR.05015-11 - DOI - PMC - PubMed
    1. Sinha P, Matthay MA, Calfee CS. Is a “cytokine storm” relevant to COVID-19? JAMA Intern Med. Published online June 30, 2020. doi:10.1001/jamainternmed.2020.3313 - DOI - PubMed
    1. Khan SS, Smith MS, Reda D, Suffredini AF, McCoy JP Jr. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers. Cytometry B Clin Cytom. 2004;61(1):35-39. doi:10.1002/cyto.b.20021 - DOI - PubMed
    1. Habes QLM, van Ede L, Gerretsen J, Kox M, Pickkers P. Norepinephrine contributes to enterocyte damage in septic shock patients: a prospective cohort study. Shock. 2018;49(2):137-143. doi:10.1097/SHK.0000000000000955 - DOI - PubMed
    1. Timmermans K, Kox M, Vaneker M, et al. . Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients. Intensive Care Med. 2016;42(4):551-561. doi:10.1007/s00134-015-4205-3 - DOI - PMC - PubMed