Breakthrough Hormographiella aspergillata Infection in a Patient with Acute Myeloid Leukemia Receiving Posaconazole Prophylaxis: A Case Report and Review

Mycopathologia. 2020 Dec;185(6):1069-1076. doi: 10.1007/s11046-020-00488-z. Epub 2020 Sep 3.

Abstract

Breakthrough invasive infections occur in immunosuppressed patients while they are receiving antifungal agents for both prophylaxis and therapy. Under such conditions, unusual fungal infections emerge. Hormographiella aspergillata is considered an uncommon human pathogen and causes devastating infections. Here, we present a case report of necrotizing pneumonia caused by H. aspergillata as a breakthrough infection in a neutropenic patient and review all previous cases of H. aspergillata infection reported in the literature.

Keywords: Antifungal; Breakthrough; Hormographiella aspergillata; Pneumonia; Posaconazole; Prophylaxis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Agaricales
  • Antifungal Agents* / therapeutic use
  • Humans
  • Leukemia, Myeloid, Acute* / complications
  • Leukemia, Myeloid, Acute* / drug therapy
  • Mycoses / drug therapy*
  • Pneumonia, Necrotizing / drug therapy*
  • Pneumonia, Necrotizing / microbiology
  • Triazoles / therapeutic use*

Substances

  • Antifungal Agents
  • Triazoles
  • posaconazole

Supplementary concepts

  • Coprinopsis cinerea