Effectiveness of insecticide-impregnated dog collars in reducing incidence rate of canine visceral leishmaniasis: A systematic review and meta-analysis

PLoS One. 2020 Sep 3;15(9):e0238601. doi: 10.1371/journal.pone.0238601. eCollection 2020.

Abstract

Canines are proven reservoir hosts of Leishmania infantum, the causative agent of human zoonotic visceral leishmaniasis, and therefore domestic dogs play a central role in transmitting the disease to humans. Studies on the effect of insecticide-impregnated dog collars for controlling canine visceral leishmaniasis (CanL) have been increasing; however, meta-analysis has not been conducted. This study assessed the effectiveness of insecticide-impregnated dog collars for preventing CanL. We searched (PubMed, Web of Science, Scopus, Embase, Ovid Medline(R), and Cochrane library), from inception until 2 May 2020. Two authors independently performed articles screening and data extraction. We applied the RoB 2.0 tool to evaluate the risk of bias in randomized trials, while the ROBINS-I tool was used for non-randomized trials. I-squared statistics(I2) and funnel plot and Egger's test, respectively, were used to assesses heterogeneity between studies and publication bias. Relative Risk (RR) and 95% Confidence Interval (CI) were calculated using the random-effects model in Stata 14 software. Out of 242 citations identified, 14 studies comprising 3786 collared dogs and 3428 uncollared dogs were eligible for meta-analysis. The use of deltamethrin-impregnated dog collars(DMC) showed an overall effectiveness of 54% (95%CI: 35-65%, I2 = 63.2%, P = 0.002) in decreasing incidence of CanL, while 10% imidacloprid and 4.5% flumethrin collars provided an overall effectiveness of 90% (95%CI: 80-96%, I2 = 0.0%, P = 0.376). DMC efficacy stratified by follow-up duration was estimated to be 58% (RR = 0.42, 95%CI: 0.20-0.87), 54% (RR = 0.46, 95%CI: 0.31-0.68), 53% (RR = 0.47, 95%CI: 0.29-0.82) for follow-up periods of 5 to 6 months, 1 year and 2 years, respectively. The current evidence indicates that using insecticide-impregnated dog collars can reduce the risk of CanL caused by L. infantum. Therefore, insecticide-impregnated dog collars could be a viable alternative for inclusion as a public health measure for controlling CanL.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Dog Diseases / parasitology
  • Dog Diseases / prevention & control*
  • Dogs
  • Insecticides / pharmacology*
  • Leishmania infantum / drug effects*
  • Leishmaniasis, Visceral / prevention & control*
  • Leishmaniasis, Visceral / veterinary
  • Neonicotinoids / pharmacology
  • Nitriles / pharmacology
  • Nitro Compounds / pharmacology
  • Pyrethrins / pharmacology

Substances

  • Insecticides
  • Neonicotinoids
  • Nitriles
  • Nitro Compounds
  • Pyrethrins
  • decamethrin
  • flumethrin
  • imidacloprid

Grant support

The authors received no specific funding for this work.