Topical Over-the-Counter Antiaging Agents: An Update and Systematic Review

Dermatology. 2021;237(2):217-229. doi: 10.1159/000509296. Epub 2020 Sep 3.

Abstract

Over-the-counter antiaging formulations aim to prevent or minimize the signs of aging skin, and to maintain the benefits obtained from different cosmetic procedures. Even though a huge selection of such products is available on the market, evidence and good clinical practice of the data supporting their use are oftentimes lacking. In this systematic review, the authors reviewed scientific data available in the published literature on the most common ingredients used in antiaging cosmetics, with a particular focus on in vivo studies.

Keywords: Antiaging; Cosmeceutical; Rejuvenational capacity; Targeted ingredients.

Publication types

  • Systematic Review

MeSH terms

  • Administration, Cutaneous
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Humans
  • Hyaluronic Acid / therapeutic use
  • Nonprescription Drugs / administration & dosage
  • Nonprescription Drugs / therapeutic use*
  • Peptides / administration & dosage
  • Peptides / therapeutic use*
  • Phenols / therapeutic use
  • Phytochemicals / administration & dosage
  • Phytochemicals / therapeutic use*
  • Retinoids / administration & dosage
  • Retinoids / therapeutic use*
  • Skin Aging / drug effects*
  • Ubiquinone / analogs & derivatives
  • Ubiquinone / therapeutic use

Substances

  • Antioxidants
  • Nonprescription Drugs
  • Peptides
  • Phenols
  • Phytochemicals
  • Retinoids
  • Ubiquinone
  • Hyaluronic Acid
  • coenzyme Q10